KDM4B INHIBITOR COMPOUND B3

Name	NCGC00244536
Synonyms	CS-2874 KDM4B-IN-B3 NCGC00244536 KDM4B Inhibitor B3 KDM4B INHIBITOR COMPOUND B3 Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
CAS	2003260-55-5

Molecular Formula	C25H22N2O2
Molar Mass	382.45
Density	1?+-.0.06 g/cm3(Predicted)
Boling Point	646.9±55.0 °C(Predicted)
Solubility	Soluble in DMSO
pKa	4.81±0.40(Predicted)
Storage Condition	Room Temprature
In vitro study	NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC 50 =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC 50 s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC 50 s.
In vivo study	Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis.

NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM

Last Update：2022-10-16 17:42:01

biological activity	NCGC00244536 is a highly effective KDM4B inhibitor with an IC50 value of 10 nM.
target	IC50: 10 nM (KDM4B)
in vitro study	NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC 50=40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC 50 s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC 50 s.
in vivo study	Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis.

Last Update：2024-04-09 21:50:46

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CAS: 2003260-55-5
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Product Name: NCGC00244536 Visit Supplier Webpage Request for quotation
CAS: 2003260-55-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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KDM4B INHIBITOR COMPOUND B3

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